Effect of 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) on Influenza Virus Host Resistance in Mice
Identifieur interne : 001C72 ( Main/Exploration ); précédent : 001C71; suivant : 001C73Effect of 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) on Influenza Virus Host Resistance in Mice
Auteurs : Gary R. Burleson [États-Unis] ; Hervé Lebrec [États-Unis] ; Yung G. Yang [États-Unis] ; Joelle D. Ibanes [États-Unis] ; Kevin N. Pennington [États-Unis] ; Linda S. Birnbaum [États-Unis]Source :
- Fundamental and Applied Toxicology [ 0272-0590 ] ; 1996.
English descriptors
- Teeft :
- Acute tcdd toxicity, Appl, Burleson, Cause mortality, Chapel hill, Cytokine, Cytokine release syndrome, Data point, Dos, Endotoxin hypersensitivity, Environmental protection agency, Ftoxa, Herpes simplex, Host resistance, Host resistance studies, Immune, Immune responses, Immunotoxic effects, Infectious disease, Influenza virus host resistance, Intranasal infection, Kerkvliet, Lung weight ratio, Lymphocyte, Mortality, Mouse, Noael, Pharmacol, Present address, Present study, Research triangle park, Risk assessment, Single dose, Standard error, Statistical analysis, Stock virus, Susceptibility, Tcdd, Tcdd administration, Tcdd exposure, Thymic, Thymic atrophy, Thymus, Thymus weight, Total dose, Toxicol, Toxicology, Viral, Viral disease, Viral replication, Virus, Virus dilution, Virus host resistance, Virus host resistance model, Virus infection, Virus titers, Wyde.
Abstract
Abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes numerous immunotoxic effects including thymic involution and an immunosuppression of nonspecific as well as specific cell- and humoral-mediated immunity. TCDD administration to laboratory animals also results in a decreased resistance to numerous bacteria, viruses, and parasites. Effects on virus host resistance appear to be among the most sensitive effects of TCDD immunotoxicity. However, previous studies have not achieved a no effect level. The present studies utilized an influenza virus host resistance model in mice to quantify the sensitivity of this model to TCDD and to determine the NOAEL (no observed adverse effect level) of TCDD for influenza virus. Results indicated that a single dose of TCDD at 0.10, 0.05, or 0.01 μg/kg resulted in an increased mortality to Hong Kong influenza virus when mice were challenged 7 days after TCDD administration. Increased mortality was not correlated with increased virus titers in the lungs. TCDD at 0.005 or 0.001 μg/kg had no effect on influenza-induced mortality. TCDD alone did not affect thymus weight at any dose administered in this study. TCDD also did not alter the virus-enhanced increase in lung weight:body weight ratio nor the virus-induced decrease in thymus weight. Thus, low levels of TCDD exposure lead to enhanced mortality to influenza virus; however, the mechanism of this effect remains to be elucidated. Nonetheless, enhanced mortality to influenza virus in mice following a single dose of 10 ng TCDD/kg represents the most sensitive adverse effect yet reported for TCDD.
Url:
DOI: 10.1006/faat.1996.0004
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes numerous immunotoxic effects including thymic involution and an immunosuppression of nonspecific as well as specific cell- and humoral-mediated immunity. TCDD administration to laboratory animals also results in a decreased resistance to numerous bacteria, viruses, and parasites. Effects on virus host resistance appear to be among the most sensitive effects of TCDD immunotoxicity. However, previous studies have not achieved a no effect level. The present studies utilized an influenza virus host resistance model in mice to quantify the sensitivity of this model to TCDD and to determine the NOAEL (no observed adverse effect level) of TCDD for influenza virus. Results indicated that a single dose of TCDD at 0.10, 0.05, or 0.01 μg/kg resulted in an increased mortality to Hong Kong influenza virus when mice were challenged 7 days after TCDD administration. Increased mortality was not correlated with increased virus titers in the lungs. TCDD at 0.005 or 0.001 μg/kg had no effect on influenza-induced mortality. TCDD alone did not affect thymus weight at any dose administered in this study. TCDD also did not alter the virus-enhanced increase in lung weight:body weight ratio nor the virus-induced decrease in thymus weight. Thus, low levels of TCDD exposure lead to enhanced mortality to influenza virus; however, the mechanism of this effect remains to be elucidated. Nonetheless, enhanced mortality to influenza virus in mice following a single dose of 10 ng TCDD/kg represents the most sensitive adverse effect yet reported for TCDD.</div>
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